The University Retina Clinical Trials Program

Within the past 3 years, University Retina has built their program to be one of the largest clinical trial programs in the Midwest for retinal and macular conditions.

We have a full-time team dedicated to our Clinical Trials program and are able to offer our patients the latest innovative drug and medical device therapeutics for treating retinal and macular diseases. If you are interested in learning more or participating in a clinical trial for macular or retinal disease, please contact us using the button below.

Director of Clinical Research
Veeral Sheth, MD, FACS

 

What are Clinical Trials?

Clinical trials are research studies that look into advanced and cutting edge treatments for diseases of the macula or retina that are not offered to the general public. Clinical trials are generally sponsored by governmental agencies such as the National Institute of Health (NIH), pharmaceutical companies, or non-profit institutions. These therapies may not be currently approved by the Food and Drug Administration (FDA), and data from these studies is often used to help obtain FDA approval.

Participation in clinical trials is never mandatory; our patients only participate if they choose to do so. University Retina, its staff, physicians, and patients participate in clinical trials in order to be able to offer our patients with the latest therapies available for macular diseases and retinal diseases.

How can I participate in a Clinical Trial at University Retina?

Patients that are interested in clinical trials should contact us to schedule an appointment at (708) 687-2222. Please set up an appointment to be evaluated if you are interested in participating, and we will determine whether you qualify for one of our active and enrolling clinical trials.

Please note that not everyone who wishes to participate will be eligible to participate in the trial, as the criteria for inclusion in the trial are often very strict. Regardless of whether you are able to participate or not, the University Retina team is committed to helping all of our patients with their retinal care.

Current Studies

  • NEW DAY Study: A Randomized, Masked, Controlled Study of Intravitreal ILUVIEN® Implant as Baseline Therapy in Patients With Early Diabetic Macular Edema (DME)

  • Pavilion Study: A Phase III, Multicenter, Randomized Study of the Efficacy, Safety, and Pharmacokinetics of the Port Delivery System With Ranibizumab in Patients With Diabetic Retinopathy

  • Cool-3 Study: Long Term Evaluation of Efficacy of Cooling Anesthesia for Local Anesthesia During Intravitreal Injection

  • Catalina (NGM621-GA-201): A Phase 2 Multicenter, Randomized, Double-Masked, Sham-Controlled Study of the Safety and Efficacy of Intravitreal Injections of NGM621 in Subjects With Geographic Atrophy (GA) Secondary to Age-Related Macular Degeneration (AMD)

  • Candela: A Randomized, Single-Masked, Active-Controlled Phase 2 Study of the Safety, Tolerability, and Efficacy of Repeated Doses of High-Dose Aflibercept in Patients With Neovascular Age-Related Macular Degeneration

  • Canberra: A Randomized, Double-Masked, 48-Week, Parallel-Group, Placebo-Controlled, Proof-of-Concept Study to Investigate the Efficacy and Safety of RG7774 in Patients With Diabetes Mellitus Type 1 or Type 2 With Treatment-Naive Diabetic Retinopathy-ORAL THERAPY

  • Pagoda Study: A Phase III, Multicenter, Randomized, Visual Assessor-Masked, Active-comparator Study of the Efficacy, Safety, and Pharmacokinetics of the Port Delivery System with Ranibizumab in Patients With Diabetic Macular Edema. Sponsor: Genentech/Roche

    Norse Two Study: A Clinical Effectiveness, Multicenter, Randomized, Double-masked, Controlled Study of the Efficacy and Safety of ONS-5010 in Subjects with Subfoveal Choroidal Neovascularization (CNV) Secondary to Age-related Macular Degeneration.  Sponsor: Outlook Therapeutics

    Salutartis: A Prospective Study of Episcleral Brachytherapy for the Treatment of Neovascular Age-related Macular Degeneration.  Sponsor: Salutaris Medical Devices

  • Gallego Study: A Phase II, Multicenter, Randomized, Single-Masked, Sham-Controlled Study to Assess Safety, Tolerability, and Efficacy of Intravitreal Injections of FHTR2163 in Patients with Geographic Atrophy Secondary to Age-Related Macular Degeneration. Sponsor: Genentech/Roche

  • Altissimo: A Phase 2b Multicenter Dose-Ranging Study Evaluating the Safety and Efficacy of Sunitinib Malate Depot Formulation (GB-102) Compared to Aflibercept in Subjects with Neovascular (Wet) Age-related Macular Degeneration (ALTISSIMO Study).  Sponsor: Graybug Vision

  • GTSCOPE: A Study of Disease Progression in Genetically Defined Subjects with Geographic Atrophy (GA) Secondary to Age-related Macular Degeneration.  Sponsor: Gyroscope Therapeutics

  • Ionis: A Phase 2, Randomized Placebo-Controlled, Double-Masked Study to Assess Safety and Efficacy of Multiple Doses of IONIS-FB-LRx, an Antisense Inhibitor of Complement Factor B, in Patients with Geographic Atrophy Secondary to Age-Related Macular Degeneration (AMD).  Sponsor: Ionis Pharmaceuticals

  • Kingfisher Study: A 12-Month, 2-Arm, Randomized, Double-Masked, Multicenter Phase III Study Assessing the Efficacy and Safety of Brolucizumab vs. Aflibercept in Patients with Visual Impairment Due to Diabetic Macular Edema.  Sponsor: Novartis

  • Lucerne Study: A Phase III, Multicenter, Randomized, Double-Masked, Active Comparator-Controlled Study to Evaluate the Efficacy and Safety of Faricimab in Patients with Neovascular Age-Related Macular Degeneration. Sponsor: Genentech/Roche

  • Archway Study: A Phase III, Multicenter, Randomized, Visual Assessor-Masked, Active-Comparator Study of the Efficacy, Safety, and Pharmacokinetics of the Port Delivery System with Ranibizumab in Patients With Neovascular Age-Related Macular Degeneration. Sponsor: Genentech/Roche

  • Rhine Study: A Phase III, Multicenter, Randomized, Double-Masked, Active Comparator-Controlled Study to Evaluate the Efficacy and Safety of RO6867461 in Patients with Diabetic Macular Edema. Sponsor: Genentech/Roche

  • Panda 1: A Multicenter, Double-Masked, Randomized, Dose-Ranging Trial to Evaluate the Efficacy and Safety of Conbercept Intravitreal Injection in Subjects with Neovascular Age-related Macular Degeneration. Sponsor: Chengdu Kanghong

Past Studies

  • Topaz Study: Phase 3, multicenter, randomized, masked, controlled, parallel group study of suprachoroidal (SC) CLS-TA administered with intravitreal (IVT) anti-VEGF agent in subjects with treatment naive RVO vs. IVT anti-VEGF agent used alone. Sponsor: Clearside Biomedical

  • Cedar Study: A phase 3, multicenter, study of abicipar pegol in patients with neovascular age-related macular degeneration.  Sponsor: Allergan

  • Panorama: A phase 3, double-masked, randomized study of the efficacy and safety of intravitreal aflibercept injection in patients with moderately severe to severe nonproliferative diabetic retinopathy. Sponsor: Regeneron

  • Boulevard: A multiple center, multiple dose, randomized, active comparator controlled, double-masked, parallel group, 24-week study to investigate the safety, tolerability, pharmacokinetics, and efficacy of RO6867461 administered intravtireally in patients with diabetic macular edema. Sponsor: Genentech/Roche

  • Chroma: A phase 3, multicenter, randomized double-masked sham-controlled study to assess the efficacy and safety of lampalizumab administered intravitreally to patients with geographic atrophy secondary to age-related macular degeneration. Sponsor: Genentech/Roche

  • Onyx: A randomized, double-masked, active-controlled phase 2 study of the efficacy, safety, and tolerability of repeated doses of intravitreal REGN910-3 in patients with neovascular age-related macular degeneration. Sponsor: Regeneron

    Phase 2, randomized, double-masked, vehicle-controlled, proof of concept study for topically delivered LHA510 as a maintenance therapy in wet AMD. Sponsor: Alcon

  • Capella: a phase 2, double-masked, randomized, controlled, multiple-dose, regimen-ranging study of the efficacy and safety of intravitreal REGN2176-3 in patients with neovascular age-related macular degeneration. Sponsor: Regeneron.

  • Protocol OPH1006: An 18 month phase 2a open label, randomized study of Avastin, Lucentis, or Eylea (anti-VEGF therapy) administered in combination with Fovista (anti-PDGF BB pegylated aptamer). Sponsor: Ophthotech.

  • Protocol OPH1005: Phase 2A open label safety study of Fovista (anti-PDGF BB) regimen administered in combination with anti-VEGF therapy to study sub-retinal fibrosis in neovascular AMD. Sponsor: Ophthotech

  • Protocol OPH1004: A phase 3 safety and efficacy study of Fovista intravitreous administration in combination with either Avastin or Eylea compared to Avastin or Eylea monotherapy. Sponsor: Ophthotech

  • ORBIT study: Phase 4 study of intravtireal Jetrea for vitreomacular adhesion.  Sponsor: Thrombogenics

  • Diabetic Retinopathy Clinical Research Network (DRCR.net): A collaborative network dedicated to facilitating multicenter clinical research of diabetic retinopathy, diabetic macular edema and associated conditions. Protocols R, V, U, and AC. Sponsor: NEI.